Journal Top Ten -- COLUMNS-Drugs & Supplements -- September 2006

ARTICLE: 'Randomized controlled trial of effect of prescription of clozapine versus other second-generation antipsychotic drugs in resistant schizophrenia'

JOURNAL:Schizophrenia Bulletin. 2006 Oct;32(4):715-23.

SUMMARY:There is good evidence that clozapine is more efficacious than first-generation antipsychotic drugs in resistant schizophrenia. It is less clear if clozapine is more effective than the other second-generation antipsychotic (SGA) drugs. The trial was conducted in the United Kingdom National Health Service. Participants were 136 people aged 18 to 65 with DSM-IV schizophrenia and related disorders whose medication was being changed because of poor clinical response to two …