Journal Top Ten -- Columns-Drugs & Supplements -- December 2003

1 Related Drug: Avandia

photo-1Article: Rosiglitazone Activates Renal Sodium- and Water-Reabsorptive Pathways and Lowers Blood Pressure in Normal Rats

Summary: The article describes the results of a study designed to test whether rosiglitazone (Avandia, GSK) may be associated with fluid retention and edema by activating sodium and water reabsorptive processes in the kidney, possibly as a response to a drop in arterial blood pressure. Researchers administered rosiglitazone (47 or 94 mg/kg diet) to male Sprague-Dawley rats for three days and measure the mean arterial blood pressure. The article stated that the mean arterial blood pressure decreased significantly …


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