Journal Top Ten - December 2002

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1 RELATED DRUG: Lariam ARTICLE: Neuropsychiatric Events During Prophylactic Use of Mefloquine Before Travelling SUMMARY: A study that investigated the adverse neuropsychiatric events experienced in men and women who used mefloquine in the three-week prophylactic period that precedes travelling. The investigation also examined whether first-time users of mefloquine were at a greater risk of adverse neuropsychiatric events compared to individuals who had previous exposure to the drug. The study was conducted from May 1999 to March 2000 and requested that the subjects describe any adverse event in a journal. The conclusions, which were based on …