Journal Top Ten -- COLUMNS-Drugs --November 2007

1
Avandia

ARTICLE: 'Does Rosiglitazone Increase Cardiovascular Outcomes?'

JOURNAL: Expert Opinion on Pharmacotherapy 2007 Oct;8(15):2665-9

SUMMARY: The Australian review investigates the recent meta-analysis that led researchers to conclude that there is an increased risk of cardiovascular injury associated with Avandia use. The author notes the limitations of the meta-analysis and interim analysis and concludes that while it seems possible that Avandia may have a small harmful effect on cardiovascular outcome, the recent data should not be cause for alarm, but for further review of how the drug should be used and for further, larger trials to determine …